If you're talking gang activity, I'd stay away from anything south of Maizeland and Academy. Downtown is ok, and most of the stuff north of Austin Bluffs and Academy is fine. CS isn't massively unsafe, but to quote my grandmother 'nothing good ever happens after midnight' - so take that under advisement about hanging out late at night.
The best way to evaluate a neighborhood for renting/owning is to park your car and walk around the block and eyeball the houses and people.
Colo Springs, CO