On older bikes I weld a 2" piece of 1/4' rod to the left rear axle head. I bend the tip of the rod so that it fits just inside of the tire adjustment sliders. With this installed it only takes 1 wrench to get the rear tire off/on because it prevents the axle from spinning while trying to loosen the bolt. Manufacturers seem to have gone to a similar set up the newer bikes. Just keeps some "wrench weight" off your back.
1970 FJ40- TBA