Yes L43 Dean, it IS possible!
Spied in Boulder. Snapped some photos and left a note. No call or email yet, but fingers crossed. Did not have a decent camera and cell phone photos are terrible to see what was going on. But didn't seem like he needed a sub frame, bed rail adapters or anything. The 'Nest was sitting right on the bed rails as far as I could see. Very clean installation, in fact it was a very clean 'Nest.
'91 Toyota Pickup
'09 Kawasaki KLR650
'12 Gunnar Rockhound 29
"They say the test of literary power is whether a man can write an inscription. I say, 'Can he name a kitten?'" -- Samuel Butler